Generated by All in One SEO v4.9.10, this is an llms.txt file, used by LLMs to index the site. # VIROVEK BAC-TO-AAV Technology For Large Scale AAV Production ## Sitemaps - [XML Sitemap](https://virovek.com/sitemap.xml): Contains all public & indexable URLs for this website. ## Posts - [AAVivo to Present Groundbreaking In Vivo CAR-T Data at ASGCT 2026 Annual Meeting in Boston](https://virovek.com/2026/03/31/aavivo-symposium-asgct-2026-boston/) - AAVivo, a Delaware-registered biotechnology company focused on next-generation AAV-based gene therapies and supported by Virovek, today announced that it will host a sponsored symposium at the American Society of Gene & Cell Therapy (ASGCT) 2026 Annual Meeting, taking place May 11–15, 2026, in Boston, Massachusetts. - [Join Virovek at the ASGCT Annual Meeting May 13-17](https://virovek.com/2025/02/15/join-virovek-at-the-american-society-of-gene-and-cell-therapys-asgct-annual-meeting-may-13-17/) - Join Virovek at TThe American Society of Gene and Cell Therapy’s (ASGCT) Annual Meeting is the premier event for gene and cell therapy professionals. The meeting is the best place for people in the field to learn from the latest scientific research, stay current on new technologies, and make career-advancing connections with peers. - [Join Virovek at the American Biomanufacturing Summit April 15-16](https://virovek.com/2025/02/24/join-virovek-at-the-american-biomanufacturing-summit-april-15-16/) - Join Virovek and over 200 biopharma and biotech executive leaders at our annual biomanufacturing conference! Over our two-day event, top biopharma executives and solution providers come together to discuss emerging key trends, challenges, opportunities, and innovations in the biotechnology industry. - [Virovek announces the appointment of Peter L. Hoang as CEO](https://virovek.com/2023/10/02/virovek-announces-the-appointment-of-peter-l-hoang-as-ceo/) - Virovek, a commercial-stage biotechnology company specializing in the development, manufacturing and sale of custom-made AAV- and lentivirus-based vectors for therapeutic development, today announced that the Company has appointed Peter L. Hoang as its Chief Executive Officer. - [Kinetics and MR-Based Monitoring of AAV9 Vector Delivery into Cerebrospinal Fluid of Nonhuman Primates](https://virovek.com/2020/08/02/4667-2/) - Here we evaluated the utility of MRI to monitor intrathecal infusions in nonhuman primates. Adeno-associated virus (AAV) spiked with gadoteridol, a gadolinium-based MRI contrast agent, enabled real-time visualization of infusions delivered either via cerebromedullary cistern, lumbar, cerebromedullary and lumbar, or intracerebroventricular infusion. - [TPP Combined with DGUC as an Economic and Universal Process for Large-Scale Purification of AAV Vectors](https://virovek.com/2020/08/02/tpp-combined-with-dguc-as-an-economic-and-universal-process-for-large-scale-purification-of-aav-vectors/) - Adeno-associated virus (AAV) vectors have been commonly purified through density gradient ultracentrifugation (DGUC) or column chromatography methods. Although the DGUC method can efficiently separate the empty from the full virus particles, its application in large-scale AAV purification is hindered due to its limitation in volume of each centrifuge tube. - [Exploiting the intron-splicing mechanism of insect cells to produce viral vectors harboring toxic genes for suicide gene therapy](https://virovek.com/2020/08/02/exploiting-the-intron-splicing-mechanism-of-insect-cells-to-produce-viral-vectors-harboring-toxic-genes-for-suicide-gene-therapy/) - Exploiting the intron-splicing mechanism of insect cells to produce viral vectors harboring toxic genes for suicide gene therapy Chen H. Mol Ther Nucleic Acids. 2012 Nov 27;1:e57. - [Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons](https://virovek.com/2020/08/02/mutant-huntingtin-enhances-activation-of-dendritic-kv4-k-channels-in-striatal-spiny-projection-neurons/) - Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons Luis Carrillo-Reid, Michelle Day, Zhong Xie, Alexandria E Melendez, Jyothisri Kondapalli, Joshua L Plotkin, David L Wokosin, Yu Chen, Geraldine J Kress, Michael Kaplitt, Ema Ilijic, Jaime N Guzman, C Savio Chan, D James Surmeier eLife. 2019; 8: e40818. Published online - [Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice](https://virovek.com/2021/09/04/highly-efficient-neuronal-gene-knockout-in-vivo-by-crispr-cas9-via-neonatal-intracerebroventricular-injection-of-aav-in-mice/) - Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice Sam Hana, Michael Peterson, Helen McLaughlin, Eric Marshall, Attila J. Fabian, Olivia McKissick, Kathryn Koszka, Galina Marsh, Michael Craft, Shanqin Xu, Alexander Sorets, Tess Torregrosa, Chao Sun, Chris E. Henderson, Shih-Ching Lo Gene Ther (2021). https://doi.org/10.1038/s41434-021-00224-2 - [Intron splicing-mediated expression of AAV Rep and Cap genes and production of AAV vectors in insect cells](https://virovek.com/2020/08/02/intron-splicing-mediated-expression-of-aav-rep-and-cap-genes-and-production-of-aav-vectors-in-insect-cells/) - Intron splicing-mediated expression of AAV Rep and Cap genes and production of AAV vectors in insect cells Chen H. Mol Ther. 2008 May;16(5):924-30. Epub 2008 Mar 18. - [To transduce a zebra finch: interrogating behavioral mechanisms in a model system for speech](https://virovek.com/2020/08/02/to-transduce-a-zebra-finch-interrogating-behavioral-mechanisms-in-a-model-system-for-speech/) - To transduce a zebra finch: interrogating behavioral mechanisms in a model system for speech Jonathan B. Heston, Stephanie A. White J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017; 203(9): 691–706. Published online 2017 Mar 7. doi: 10.1007/s00359-017-1153-0 PMCID: PMC5589492 - [TRPC3 channels critically regulate hippocampal excitability and contextual fear memory](https://virovek.com/2020/08/02/trpc3-channels-critically-regulate-hippocampal-excitability-and-contextual-fear-memory/) - TRPC3 channels critically regulate hippocampal excitability and contextual fear memory Sarah M. Neuner, Lynda A. Wilmott, Kevin A. Hope, Brian Hoffmann, Jayhong A. Chong, Joel Abramowitz, Lutz Birnbaumer, Kristen O’Connell, Andrew K. Tryba, Andrew S. Greene, C. Savio Chan, Catherine C. Kaczorowski Behav Brain Res. Author manuscript; available in PMC 2016 Mar 15. Published in - [Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships](https://virovek.com/2020/08/02/heparan-sulfate-organizes-neuronal-synapses-through-neurexin-partnerships/) - Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships Peng Zhang, Hong Lu, Rui T. Peixoto, Mary K. Pines, Yuan Ge, Shinichiro Oku, Tabrez J. Siddiqui, Yicheng Xie, Wenlan Wu, Stephanie Archer-Hartmann, Keitaro Yoshida, Kenji F. Tanaka, A. Radu Aricescu, Parastoo Azadi, Michael D. Gordon, Bernardo L. Sabatini, Rachel O.L. Wong, Ann Marie Craig Cell. 2018 - [A role for cerebellum in the hereditary dystonia DYT1](https://virovek.com/2020/08/02/a-role-for-cerebellum-in-the-hereditary-dystonia-dyt1/) - A role for cerebellum in the hereditary dystonia DYT1 Rachel Fremont, Ambika Tewari, Chantal Angueyra, Kamran Khodakhah eLife. 2017; 6: e22775. Published online 2017 Feb 15. doi: 10.7554/eLife.22775 PMCID: PMC5340526 - [FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch](https://virovek.com/2020/08/02/foxp2-isoforms-delineate-spatiotemporal-transcriptional-networks-for-vocal-learning-in-the-zebra-finch/) - FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch Zachary Daniel Burkett, Nancy F Day, Todd Haswell Kimball, Caitlin M Aamodt, Jonathan B Heston, Austin T Hilliard, Xinshu Xiao, Stephanie A White eLife. 2018; 7: e30649. Published online 2018 Jan 23. doi: 10.7554/eLife.30649 - [Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress](https://virovek.com/2020/08/02/systemic-isradipine-treatment-diminishes-calcium-dependent-mitochondrial-oxidant-stress/) - Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress Jaime N. Guzman, Ema Ilijic, Ben Yang, Javier Sanchez-Padilla, David Wokosin, Dan Galtieri, Jyothisri Kondapalli, Paul T. Schumacker, D. James Surmeier J Clin Invest. 2018 Jun 1; 128(6): 2266–2280. Published online 2018 Apr 30. doi: 10.1172/JCI95898 PMCID: PMC5983329 - [Behavior-Linked FoxP2 Regulation Enables Zebra Finch Vocal Learning](https://virovek.com/2020/08/02/behavior-linked-foxp2-regulation-enables-zebra-finch-vocal-learning/) - Behavior-Linked FoxP2 Regulation Enables Zebra Finch Vocal Learning Jonathan B. Heston, Stephanie A. White J Neurosci. 2015 Feb 18; 35(7): 2885–2894. doi: 10.1523/JNEUROSCI.3715-14.2015 PMCID: PMC4331621 - [Proteomics Analysis of Co-Purifying Cellular Proteins Associated with rAAV Vectors](https://virovek.com/2020/08/02/proteomics-analysis-of-co-purifying-cellular-proteins-associated-with-raav-vectors/) - Proteomics Analysis of Co-Purifying Cellular Proteins Associated with rAAV Vectors Biao Dong, Xunbao Duan, Hoi Yee Chow, Lingxia Chen, Hui Lu, Wenman Wu, Bernd Hauck, Fraser Wright, Philipp Kapranov, Weidong Xiao PLoS One. 2014; 9(2): e86453. Published online 2014 Feb 3. doi: 10.1371/journal.pone.0086453 PMCID: PMC3911921 - [Wilm’s tumor 1 promotes memory flexibility](https://virovek.com/2020/08/02/wilms-tumor-1-promotes-memory-flexibility/) - Wilm’s tumor 1 promotes memory flexibility Chiara Mariottini, Leonardo Munari, Ellen Gunzel, Joseph M. Seco, Nikos Tzavaras, Jens Hansen, Sarah A. Stern, Virginia Gao, Hossein Aleyasin, Ali Sharma, Evren U. Azeloglu, Georgia E. Hodes, Scott J. Russo, Vicki Huff, Marc R. Birtwistle, Robert D. Blitzer, Cristina M. Alberini, Ravi Iyengar Nat Commun. 2019; 10: 3756. - [Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates](https://virovek.com/2020/08/02/viral-mediated-optogenetic-stimulation-of-peripheral-motor-nerves-in-non-human-primates/) - Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates Jordan J. Williams, Alan M. Watson, Alberto L. Vazquez, Andrew B. Schwartz Front Neurosci. 2019; 13: 759. Published online 2019 Jul 31. doi: 10.3389/fnins.2019.00759 PMCID: PMC6684788 - [Optogenetic Peripheral Nerve Immunogenicity](https://virovek.com/2020/08/02/optogenetic-peripheral-nerve-immunogenicity/) - Optogenetic Peripheral Nerve Immunogenicity Benjamin E. Maimon, Maurizio Diaz, Emilie C. M. Revol, Alexis M. Schneider, Ben Leaker, Claudia E. Varela, Shriya Srinivasan, Matthew B. Weber, Hugh M. Herr Sci Rep. 2018; 8: 14076. Published online 2018 Sep 19. doi: 10.1038/s41598-018-32075-0 PMCID: PMC6145901 - [Bidirectional scaling of vocal variability by an avian cortico‐basal ganglia circuit](https://virovek.com/2020/08/02/bidirectional-scaling-of-vocal-variability-by-an-avian-cortico‐basal-ganglia-circuit/) - Bidirectional scaling of vocal variability by an avian cortico‐basal ganglia circuit Jonathan B. Heston, Joseph Simon, IV, Nancy F. Day, Melissa J. Coleman, Stephanie A. White Physiol Rep. 2018 Apr; 6(8): e13638. Published online 2018 Apr 24. doi: 10.14814/phy2.13638 PMCID: PMC5913712 - [A robust activity marking system for exploring active neuronal ensembles](https://virovek.com/2020/08/02/a-robust-activity-marking-system-for-exploring-active-neuronal-ensembles/) - A robust activity marking system for exploring active neuronal ensembles Milad Rezvani, Regina Español-Suñer, Yann Malato, Laure Dumont, Andrew A. Grimm, Eike Kienle, Julia G. Bindman, Ellen Wiedtke, Bernadette Y. Hsu, Syed J. Naqvi, Robert F. Schwabe, Carlos U. Corvera, Dirk Grimm, Holger Willenbring Cell Stem Cell. Author manuscript; available in PMC 2017 Jun 2. - [In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis](https://virovek.com/2020/08/02/in-vivo-hepatic-reprogramming-of-myofibroblasts-with-aav-vectors-as-a-therapeutic-strategy-for-liver-fibrosis/) - In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis Milad Rezvani, Regina Español-Suñer, Yann Malato, Laure Dumont, Andrew A. Grimm, Eike Kienle, Julia G. Bindman, Ellen Wiedtke, Bernadette Y. Hsu, Syed J. Naqvi, Robert F. Schwabe, Carlos U. Corvera, Dirk Grimm, Holger Willenbring Cell Stem Cell. Author manuscript; - [Selective activation of a putative reinforcement signal conditions cued interval timing in primary visual cortex](https://virovek.com/2020/08/02/selective-activation-of-a-putative-reinforcement-signal-conditions-cued-interval-timing-in-primary-visual-cortex/) - Selective activation of a putative reinforcement signal conditions cued interval timing in primary visual cortex Cheng-Hang Liu, Jason E. Coleman, Heydar Davoudi, Kechen Zhang, Marshall G. Hussain Shuler Curr Biol. Author manuscript; available in PMC 2016 Jun 15. Published in final edited form as: Curr Biol. 2015 Jun 15; 25(12): 1551–1561. Published online 2015 May - [Acute cerebellar knockdown of Sgce reproduces salient features of myoclonus-dystonia (DYT11) in mice](https://virovek.com/2020/08/02/acute-cerebellar-knockdown-of-sgce-reproduces-salient-features-of-myoclonus-dystonia-dyt11-in-mice/) - Acute cerebellar knockdown of Sgce reproduces salient features of myoclonus-dystonia (DYT11) in mice Samantha Washburn, Rachel Fremont, Maria Camila Moreno-Escobar, Chantal Angueyra, Kamran Khodakhah eLife. 2019; 8: e52101. Published online 2019 Dec 23. doi: 10.7554/eLife.52101 PMCID: PMC6959989 - [Aberrant Purkinje cell activity is the cause of dystonia in a shRNA-based mouse model of Rapid Onset Dystonia-Parkinsonism](https://virovek.com/2020/08/02/aberrant-purkinje-cell-activity-is-the-cause-of-dystonia-in-a-shrna-based-mouse-model-of-rapid-onset-dystonia-parkinsonism/) - Aberrant Purkinje cell activity is the cause of dystonia in a shRNA-based mouse model of Rapid Onset Dystonia-Parkinsonism Rachel Fremont, Ambika Tewari, Kamran Khodakhah Neurobiol Dis. Author manuscript; available in PMC 2016 Oct 1. Published in final edited form as: Neurobiol Dis. 2015 Oct; 82: 200–212. Published online 2015 Jun 17. doi: 10.1016/j.nbd.2015.06.004 PMCID: PMC4641034 - [Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection](https://virovek.com/2020/08/02/cellular-selectivity-of-aav-serotypes-for-gene-delivery-in-neurons-and-astrocytes-by-neonatal-intracerebroventricular-injection/) - Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection Sean L. Hammond, Ashley N. Leek, Evan H. Richman, Ronald B. Tjalkens PLoS One. 2017; 12(12): e0188830. Published online 2017 Dec 15. doi: 10.1371/journal.pone.0188830 PMCID: PMC5731760 - [BACE2, a conditional β-secretase, contributes to Alzheimer’s disease pathogenesis](https://virovek.com/2020/08/02/bace2-a-conditional-β-secretase-contributes-to-alzheimers-disease-pathogenesis/) - BACE2, a conditional β-secretase, contributes to Alzheimer’s disease pathogenesis Zhe Wang, Qin Xu, Fang Cai, Xi Liu, Yili Wu, Weihong Song JCI Insight. 2019 Jan 10; 4(1): e123431. Published online 2019 Jan 10. doi: 10.1172/jci.insight.123431 PMCID: PMC6485359 - [Klotho controls the brain–immune system interface in the choroid plexus](https://virovek.com/2020/08/02/klotho-controls-the-brain-immune-system-interface-in-the-choroid-plexus/) - Klotho controls the brain–immune system interface in the choroid plexus Lei Zhu, Liana R. Stein, Daniel Kim, Kaitlyn Ho, Gui-Qiu Yu, Lihong Zhan, Tobias E. Larsson, Lennart Mucke Proc Natl Acad Sci U S A. 2018 Nov 27; 115(48): E11388–E11396. Published online 2018 Nov 9. doi: 10.1073/pnas.1808609115 PMCID: PMC6275534 - [Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells](https://virovek.com/2020/08/02/integration-of-a-cd19-car-into-the-tcr-alpha-chain-locus-streamlines-production-of-allogeneic-gene-edited-car-t-cells/) - Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells Daniel T. MacLeod, Jeyaraj Antony, Aaron J. Martin, Rachel J. Moser, Armin Hekele, Keith J. Wetzel, Audrey E. Brown, Melissa A. Triggiano, Jo Ann Hux, Christina D. Pham, Victor V. Bartsevich, Caitlin A. Turner, Janel Lape, - [Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions](https://virovek.com/2020/08/02/dystonia-type-6-gene-product-thap1-identification-of-a-50-kda-dna-binding-species-in-neuronal-nuclear-fractions/) - Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions Maitane Ortiz-Virumbrales, Marta Ruiz, Eugene Hone, Georgia Dolios, Rong Wang, Andrika Morant, Jessica Kottwitz, Laurie J Ozelius, Sam Gandy, Michelle E Ehrlich - [Convection-Enhanced Delivery of AAV2-PrPshRNA in Prion-Infected Mice](https://virovek.com/2020/08/02/convection-enhanced-delivery-of-aav2-prpshrna-in-prion-infected-mice/) - Convection-Enhanced Delivery of AAV2-PrPshRNA in Prion-Infected Mice Misol Ahn, Krystyna Bajsarowicz, Abby Oehler, Azucena Lemus, Krystof Bankiewicz, Stephen J. DeArmond PLoS One. 2014; 9(5): e98496. Published online 2014 May 27. doi: 10.1371/journal.pone.0098496 PMCID: PMC4035323 - [Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase](https://virovek.com/2020/08/02/mitochondrial-oxidant-stress-in-locus-coeruleus-is-regulated-by-activity-and-nitric-oxide-synthase/) - Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase J. Sanchez–Padilla, J.N. Guzman, E. Ilijic, J. Kondapalli, D.J. Galtieri, B. Yang, S. Schieber, W. Oertel, D. Wokosin, P. T. Schumacker, D. J. Surmeier Nat Neurosci. Author manuscript; available in PMC 2014 Dec 1. Published in final edited form as: Nat - [Peripheral Brain Derived Neurotrophic Factor Precursor Regulates Pain as an Inflammatory Mediator](https://virovek.com/2020/08/02/peripheral-brain-derived-neurotrophic-factor-precursor-regulates-pain-as-an-inflammatory-mediator/) - Peripheral Brain Derived Neurotrophic Factor Precursor Regulates Pain as an Inflammatory Mediator Cong Luo, Xiao-Lin Zhong, Fiona H. Zhou, Jia-yi Li, Pei Zhou, Jun-Mei Xu, Bo Song, Chang-Qi Li, Xin-Fu Zhou, Ru-Ping Dai Sci Rep. 2016; 6: 27171. Published online 2016 Jun 2. doi: 10.1038/srep27171 PMCID: PMC4890020 - [Long-term Expression of Apolipoprotein B mRNA-specific Hammerhead Ribozyme via scAAV8.2 Vector Inhibits Atherosclerosis in Mice](https://virovek.com/2020/08/02/long-term-expression-of-apolipoprotein-b-mrna-specific-hammerhead-ribozyme-via-scaav8-2-vector-inhibits-atherosclerosis-in-mice/) - Long-term Expression of Apolipoprotein B mRNA-specific Hammerhead Ribozyme via scAAV8.2 Vector Inhibits Atherosclerosis in Mice Hersharan Nischal, Hua Sun, Yuchun Wang, David A Ford, Ying Cao, Peng Wei, Ba-Bie Teng Mol Ther Nucleic Acids. 2013 Oct; 2(10): e125. Published online 2013 Oct 1. doi: 10.1038/mtna.2013.53 PMCID: PMC4027429 - [Disruption in dopaminergic innervation during photoreceptor degeneration](https://virovek.com/2020/08/02/disruption-in-dopaminergic-innervation-during-photoreceptor-degeneration/) - Disruption in dopaminergic innervation during photoreceptor degeneration Elena Ivanova, Christopher W Yee, Botir T Sagdullaev J Comp Neurol. Author manuscript; available in PMC 2017 Apr 15. Published in final edited form as: J Comp Neurol. 2016 Apr 15; 524(6): 1208–1221. Published online 2015 Sep 28. doi: 10.1002/cne.23899 PMCID: PMC4747828 - [Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons](https://virovek.com/2020/08/02/maladaptive-downregulation-of-autonomous-subthalamic-nucleus-activity-following-the-loss-of-midbrain-dopamine-neurons/) - Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons Eileen L. McIver, Jeremy F. Atherton, Hong-Yuan Chu, Kathleen E. Cosgrove, Jyothisri Kondapalli, David Wokosin, D. James Surmeier, Mark D. Bevan Cell Rep. Author manuscript; available in PMC 2019 Aug 19. Published in final edited form as: Cell Rep. 2019 Jul - [The matricellular protein CCN5 inhibits fibrotic deformation of retinal pigment epithelium](https://virovek.com/2020/08/02/the-matricellular-protein-ccn5-inhibits-fibrotic-deformation-of-retinal-pigment-epithelium/) - The matricellular protein CCN5 inhibits fibrotic deformation of retinal pigment epithelium Aeri Yoon, Sora Im, Juyeon Lee, Daeho Park, Dong Hyun Jo, Jin Hyoung Kim, Jeong Hun Kim, Woo Jin Park PLoS One. 2018; 13(12): e0208897. Published online 2018 Dec 20. doi: 10.1371/journal.pone.0208897 PMCID: PMC6301692 - [Closed-loop functional optogenetic stimulation](https://virovek.com/2020/08/02/closed-loop-functional-optogenetic-stimulation/) - Closed-loop functional optogenetic stimulation Shriya S. Srinivasan, Benjamin E. Maimon, Maurizio Diaz, Hyungeun Song, Hugh M. Herr Nat Commun. 2018; 9: 5303. Published online 2018 Dec 13. doi: 10.1038/s41467-018-07721-w PMCID: PMC6294002 - [Exosomes derived from rAAV/AFP-transfected dendritic cells elicit specific T cell-mediated immune responses against hepatocellular carcinoma](https://virovek.com/2020/08/02/exosomes-derived-from-raav-afp-transfected-dendritic-cells-elicit-specific-t-cell-mediated-immune-responses-against-hepatocellular-carcinoma/) - Exosomes derived from rAAV/AFP-transfected dendritic cells elicit specific T cell-mediated immune responses against hepatocellular carcinoma Jieyu Li, Shenglan Huang, Zhifeng Zhou, Wansong Lin, Shuping Chen, Mingshui Chen, Yunbin Ye Cancer Manag Res. 2018; 10: 4945–4957. Published online 2018 Oct 29. doi: 10.2147/CMAR.S178326 PMCID: PMC6214341 - [Suppression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Function in Thalamocortical Neurons Prevents Genetically Determined and Pharmacologically Induced Absence Seizures](https://virovek.com/2020/08/02/suppression-of-hyperpolarization-activated-cyclic-nucleotide-gated-channel-function-in-thalamocortical-neurons-prevents-genetically-determined-and-pharmacologically-induced-absence-seizures/) - Suppression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Function in Thalamocortical Neurons Prevents Genetically Determined and Pharmacologically Induced Absence Seizures François David, Nihan Çarçak, Szabina Furdan, Filiz Onat, Timothy Gould, Ádám Mészáros, Giuseppe Di Giovanni, Vivian M. Hernández, C. Savio Chan, Magor L. Lőrincz, Vincenzo Crunelli J Neurosci. 2018 Jul 25; 38(30): 6615–6627. doi: 10.1523/JNEUROSCI.0896-17.2018 PMCID: PMC6067077 - [PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse](https://virovek.com/2020/08/02/pacap-neurons-in-the-ventral-premammillary-nucleus-regulate-reproductive-function-in-the-female-mouse/) - PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse Rachel A Ross, Silvia Leon, Joseph C Madara, Danielle Schafer, Chrysanthi Fergani, Caroline A Maguire, Anne MJ Verstegen, Emily Brengle, Dong Kong, Allan E Herbison, Ursula B Kaiser, Bradford B Lowell, Victor M Navarro eLife. 2018; 7: e35960. Published online 2018 - [Site-Specific Gene Editing of Human Hematopoietic Stem Cells for X-Linked Hyper-IgM Syndrome](https://virovek.com/2020/08/02/site-specific-gene-editing-of-human-hematopoietic-stem-cells-for-x-linked-hyper-igm-syndrome/) - Site-Specific Gene Editing of Human Hematopoietic Stem Cells for X-Linked Hyper-IgM Syndrome Caroline Y. Kuo, Joseph D. Long, Beatriz Campo-Fernandez, Satiro de Oliveira, Aaron R. Cooper, Zulema Romero, Megan D. Hoban, Alok V. Joglekar, Georgia R. Lill, Michael L. Kaufman, Sorel Fitz-Gibbon, Xiaoyan Wang, Roger P. Hollis, Donald B. Kohn Cell Rep. Author manuscript; available - [A hypothalamic circuit for the circadian control of aggression](https://virovek.com/2020/08/02/a-hypothalamic-circuit-for-the-circadian-control-of-aggression/) - A hypothalamic circuit for the circadian control of aggression William D. Todd, Henning Fenselau, Joshua L. Wang, Rong Zhang, Natalia L. Machado, Anne Venner, Rebecca Y. Broadhurst, Satvinder Kaur, Timothy Lynagh, David P. Olson, Bradford B. Lowell, Patrick M. Fuller, Clifford B. Saper Nat Neurosci. Author manuscript; available in PMC 2018 Oct 9. Published in - [Inhibition of a Descending Prefrontal Circuit Prevents Ketamine-Induced Stress Resilience in Females](https://virovek.com/2020/08/02/inhibition-of-a-descending-prefrontal-circuit-prevents-ketamine-induced-stress-resilience-in-females/) - Inhibition of a Descending Prefrontal Circuit Prevents Ketamine-Induced Stress Resilience in Females S. D. Dolzani, M. V. Baratta, J. M. Moss, N. L. Leslie, S. G. Tilden, A. T. Sørensen, L. R. Watkins, Y. Lin, S. F. Maier eNeuro. 2018 Jan-Feb; 5(1): ENEURO.0025-18.2018. Prepublished online 2018 Feb 26. Published online 2018 Mar 6. doi: 10.1523/ENEURO.0025-18.2018 - [A Robust Optomotor Assay for Assessing the Efficacy of Optogenetic Tools for Vision Restoration](https://virovek.com/2020/08/02/a-robust-optomotor-assay-for-assessing-the-efficacy-of-optogenetic-tools-for-vision-restoration/) - A Robust Optomotor Assay for Assessing the Efficacy of Optogenetic Tools for Vision Restoration Qi Lu, Tushar H. Ganjawala, Samer Hattar, Gary W. 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Published online 2017 Feb 23. doi: 10.1172/jci.insight.91456 PMCID: PMC5313063 - [CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats](https://virovek.com/2020/08/02/creb-overexpression-in-dorsal-ca1-ameliorates-long-term-memory-deficits-in-aged-rats/) - CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats Xiao-Wen Yu, Daniel M Curlik, II, M Matthew Oh, Jerry CP Yin, John F Disterhoft eLife. 2017; 6: e19358. Published online 2017 Jan 4. doi: 10.7554/eLife.19358 PMCID: PMC5214885 - [Transient Activation of GABAB Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons](https://virovek.com/2020/08/02/transient-activation-of-gabab-receptors-suppresses-sk-channel-currents-in-substantia-nigra-pars-compacta-dopaminergic-neurons/) - Transient Activation of GABAB Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons Chad M. Estep, Daniel J. 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Published online 2019 Sep 3. doi: 10.18632/aging.102202 PMCID: PMC6756909 - [Delivering Cas9/sgRNA ribonucleoprotein (RNP) by lentiviral capsid-based bionanoparticles for efficient ‘hit-and-run’ genome editing](https://virovek.com/2020/08/02/delivering-cas9-sgrna-ribonucleoprotein-rnp-by-lentiviral-capsid-based-bionanoparticles-for-efficient-hit-and-run-genome-editing/) - Delivering Cas9/sgRNA ribonucleoprotein (RNP) by lentiviral capsid-based bionanoparticles for efficient ‘hit-and-run’ genome editing Pin Lyu, Parisa Javidi-Parsijani, Anthony Atala, Baisong Lu Nucleic Acids Res. 2019 Sep 26; 47(17): e99. Published online 2019 Jul 12. doi: 10.1093/nar/gkz605 PMCID: PMC6753487 - [Mechanisms of PTPσ-Mediated Presynaptic Differentiation](https://virovek.com/2020/08/02/mechanisms-of-ptpσ-mediated-presynaptic-differentiation/) - Mechanisms of PTPσ-Mediated Presynaptic Differentiation Claire Bomkamp, Nirmala Padmanabhan, Benyamin Karimi, Yuan Ge, Jesse T. Chao, Christopher J. R. 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Published online 2013 Jun 13. doi: 10.1074/jbc.M113.471904 PMCID: PMC3724629 - [Arcuate neuropeptide Y inhibits sympathetic nerve activity via multiple neuropathways](https://virovek.com/2020/08/02/arcuate-neuropeptide-y-inhibits-sympathetic-nerve-activity-via-multiple-neuropathways/) - Arcuate neuropeptide Y inhibits sympathetic nerve activity via multiple neuropathways Zhigang Shi, Christopher J. Madden, Virginia L. Brooks J Clin Invest. 2017 Jun 30; 127(7): 2868–2880. Published online 2017 Jun 19. doi: 10.1172/JCI92008 PMCID: PMC5490747 - [Generation of infectious recombinant Adeno-associated virus in Saccharomyces cerevisiae](https://virovek.com/2020/08/02/generation-of-infectious-recombinant-adeno-associated-virus-in-saccharomyces-cerevisiae/) - Generation of infectious recombinant Adeno-associated virus in Saccharomyces cerevisiae Daniel Barajas, Juan Jose Aponte-Ubillus, Hassibullah Akeefe, Tomas Cinek, Joseph Peltier, Daniel Gold PLoS One. 2017; 12(3): e0173010. Published online 2017 Mar 29. doi: 10.1371/journal.pone.0173010 PMCID: PMC5371294 - [Recombinant adeno-associated virus serotype 9 in a mouse model of atherosclerosis: Determination of the optimal expression time in vivo](https://virovek.com/2020/08/02/recombinant-adeno-associated-virus-serotype-9-in-a-mouse-model-of-atherosclerosis-determination-of-the-optimal-expression-time-in-vivo/) - Recombinant adeno-associated virus serotype 9 in a mouse model of atherosclerosis: Determination of the optimal expression time in vivo Qingjie Chen, Hui Zhai, Xiaomei Li, Yitong Ma, Bangdang Chen, Fen Liu, Hongmei Lai, Jia Xie, Chunhui He, Junyi Luo, Jing Gao, Yining Yang - [Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration](https://virovek.com/2020/08/02/mobile-zinc-increases-rapidly-in-the-retina-after-optic-nerve-injury-and-regulates-ganglion-cell-survival-and-optic-nerve-regeneration/) - Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration Yiqing Li, Lukas Andereggen, Kenya Yuki, Kumiko Omura, Yuqin Yin, Hui-Ya Gilbert, Burcu Erdogan, Maria S. Asdourian, Christine Shrock, Silmara de Lima, Ulf-Peter Apfel, Yehong Zhuo, Michal Hershfinkel, Stephen J. Lippard, Paul A. Rosenberg, Larry - [Role of Hypothalamic Creb-Binding Protein in Obesity and Molecular Reprogramming of Metabolic Substrate](https://virovek.com/2020/08/02/role-of-hypothalamic-creb-binding-protein-in-obesity-and-molecular-reprogramming-of-metabolic-substrate/) - Role of Hypothalamic Creb-Binding Protein in Obesity and Molecular Reprogramming of Metabolic Substrates Cesar L. Moreno, Linda Yang, Penny A. Dacks, Fumiko Isoda, Jan M. A. van Deursen, Charles V. Mobbs PLoS One. 2016; 11(11): e0166381. Published online 2016 Nov 10. doi: 10.1371/journal.pone.0166381 PMCID: PMC5104324 - [An Intrabody Drug (rAAV6-INT41) Reduces the Binding of N-Terminal Huntingtin Fragment(s) to DNA to Basal Levels in PC12 Cells and Delays Cognitive Loss in the R6/2 Animal Model](https://virovek.com/2020/08/02/an-intrabody-drug-raav6-int41-reduces-the-binding-of-n-terminal-huntingtin-fragments-to-dna-to-basal-levels-in-pc12-cells-and-delays-cognitive-loss-in-the-r6-2-animal-model/) - An Intrabody Drug (rAAV6-INT41) Reduces the Binding of N-Terminal Huntingtin Fragment(s) to DNA to Basal Levels in PC12 Cells and Delays Cognitive Loss in the R6/2 Animal Model I. Alexandra Amaro, Lee A. Henderson J Neurodegener Dis. 2016; 2016: 7120753. Published online 2016 Aug 10. doi: 10.1155/2016/7120753 PMCID: PMC4995342 - [High-fidelity optical excitation of cortico-cortical projections at physiological frequencies](https://virovek.com/2020/08/02/high-fidelity-optical-excitation-of-cortico-cortical-projections-at-physiological-frequencies-2/) - High-fidelity optical excitation of cortico-cortical projections at physiological frequencies Charles A. Hass, Lindsey L. Glickfeld J Neurophysiol. 2016 Nov 1; 116(5): 2056–2066. Published online 2016 Aug 3. doi: 10.1152/jn.00456.2016 PMCID: PMC5102304 - [High-fidelity optical excitation of cortico-cortical projections at physiological frequencies](https://virovek.com/2020/08/02/high-fidelity-optical-excitation-of-cortico-cortical-projections-at-physiological-frequencies/) - High-fidelity optical excitation of cortico-cortical projections at physiological frequencies Charles A. Hass, Lindsey L. Glickfeld J Neurophysiol. 2016 Nov 1; 116(5): 2056–2066. Published online 2016 Aug 3. doi: 10.1152/jn.00456.2016 PMCID: PMC5102304 - [ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress](https://virovek.com/2020/08/02/probdnf-signaling-regulates-depression-like-behaviors-in-rodents-under-chronic-stress/) - ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress Yin-Yin Bai, Chun-Sheng Ruan, Chun-Rui Yang, Jia-Yi Li, Zhi-Long Kang, Li Zhou, Dennis Liu, Yue-Qing Zeng, Ting-Hua Wang, Chang-Fu Tian, Hong Liao, Larisa Bobrovskaya, Xin-Fu Zhou Neuropsychopharmacology. 2016 Nov; 41(12): 2882–2892. Prepublished online 2016 Jun 17. Published online 2016 Jul 13. doi: 10.1038/npp.2016.100 - [Prevalence of AAV1 neutralizing antibodies and consequences for a clinical trial of gene transfer for advanced heart failure](https://virovek.com/2020/08/02/prevalence-of-aav1-neutralizing-antibodies-and-consequences-for-a-clinical-trial-of-gene-transfer-for-advanced-heart-failure/) - Prevalence of AAV1 neutralizing antibodies and consequences for a clinical trial of gene transfer for advanced heart failure B Greenberg, J Butler, GM Felker, P Ponikowski, AA Voors, JM Pogoda, R Provost, J Guerrero, RJ Hajjar, KM Zsebo Gene Ther. Author manuscript; available in PMC 2019 Jun 11. Published in final edited form as: Gene - [Increased phosphorylation of Cx36 gap junctions in the AII amacrine cells of RD retina](https://virovek.com/2020/08/02/increased-phosphorylation-of-cx36-gap-junctions-in-the-aii-amacrine-cells-of-rd-retina/) - Increased phosphorylation of Cx36 gap junctions in the AII amacrine cells of RD retina Elena Ivanova, Christopher W. Yee, Botir T. Sagdullaev Front Cell Neurosci. 2015; 9: 390. Published online 2015 Oct 1. doi: 10.3389/fncel.2015.00390 PMCID: PMC4589668 - [Inhibition of the NF-κB pathway by R65 ribozyme gene via adeno-associatedvirus serotype 9 ameliorated oxidized LDL induced human umbilical vein endothelial cell injury](https://virovek.com/2020/08/02/inhibition-of-the-nf-κb-pathway-by-r65-ribozyme-gene-via-adeno-associatedvirus-serotype-9-ameliorated-oxidized-ldl-induced-human-umbilical-vein-endothelial-cell-injury/) - Inhibition of the NF-κB pathway by R65 ribozyme gene via adeno-associatedvirus serotype 9 ameliorated oxidized LDL induced human umbilical vein endothelial cell injury Hui Zhai, Qing-Jie Chen, Xiao-Ming Gao, Yi-Tong Ma, Bang-Dang Chen, Zi-Xiang Yu, Xiao-Mei Li, Fen Liu, Yang Xiang, Jia Xie, Yi-Ning Yang Int J Clin Exp Pathol. 2015; 8(9): 9912–9921. Published online - [Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium](https://virovek.com/2020/08/02/distinct-regulation-of-dopamine-d2s-and-d2l-autoreceptor-signaling-by-calcium/) - Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium Stephanie C Gantz, Brooks G Robinson, David C Buck, James R Bunzow, Rachael L Neve, John T Williams, Kim A Neve eLife. 2015; 4: e09358. Published online 2015 Aug 26. doi: 10.7554/eLife.09358 PMCID: PMC4575989 - [FrzA gene protects cardiomyocytes from H2O2-induced oxidative stress through restraining the Wnt/Frizzled pathway](https://virovek.com/2020/08/02/frza-gene-protects-cardiomyocytes-from-h2o2-induced-oxidative-stress-through-restraining-the-wnt-frizzled-pathway/) - FrzA gene protects cardiomyocytes from H2O2-induced oxidative stress through restraining the Wnt/Frizzled pathway Jing Tao, Bang-dang Chen, Yi-tong Ma, Yi-ning Yang, Xiao-mei Li, Xiang Ma, Zi-xiang Yu, Fen Liu, Yang Xiang, You Chen Lipids Health Dis. 2015; 14: 90. Published online 2015 Aug 18. doi: 10.1186/s12944-015-0088-0 PMCID: PMC4539933 - [p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease](https://virovek.com/2020/08/02/p75ntr-ectodomain-is-a-physiological-neuroprotective-molecule-against-amyloid-beta-toxicity-in-the-brain-of-alzheimers-disease/) - p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease X-Q Yao, S-S Jiao, K Saadipour, F Zeng, Q-H Wang, C Zhu, L-L Shen, G-H Zeng, C-R Liang, J Wang, Y-H Liu, H-Y Hou, X Xu, Y-P Su, X-T Fan, H-L Xiao, L-F Lue, Y-Q Zeng, B Giunta, J-H - [A neural basis for melanocortin-4 receptor regulated appetite](https://virovek.com/2020/08/02/a-neural-basis-for-melanocortin-4-receptor-regulated-appetite/) - A neural basis for melanocortin-4 receptor regulated appetite Alastair S. Garfield, Chia Li, Joseph C. Madara, Bhavik P. Shah, Emily Webber, Jennifer S. Steger, John N. Campbell, Oksana Gavrilova, Charlotte E. Lee, David P. Olson, Joel K. Elmquist, Bakhos A. Tannous, Michael J. Krashes, Bradford B. Lowell Nat Neurosci. Author manuscript; available in PMC 2015 - [Compartment-Specific Modulation of GABAergic Synaptic Transmission by TRPV1 Channels in the Dentate Gyrus](https://virovek.com/2020/08/02/compartment-specific-modulation-of-gabaergic-synaptic-transmission-by-trpv1-channels-in-the-dentate-gyrus/) - Compartment-Specific Modulation of GABAergic Synaptic Transmission by TRPV1 Channels in the Dentate Gyrus Andrés E. Chávez, Vivian M. Hernández, Alma Rodenas-Ruano, C. Savio Chan, Pablo E. Castillo J Neurosci. 2014 Dec 10; 34(50): 16621–16629. doi: 10.1523/JNEUROSCI.3635-14.2014 PMCID: PMC4261091 - [Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD](https://virovek.com/2020/08/02/early-retinal-neurodegeneration-and-impaired-ran-mediated-nuclear-import-of-tdp-43-in-progranulin-deficient-ftld/) - Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD Michael E. Ward, Alice Taubes, Robert Chen, Bruce L. Miller, Chantelle F. Sephton, Jeffrey M. Gelfand, Sakura Minami, John Boscardin, Lauren Herl Martens, William W. Seeley, Gang Yu, Joachim Herz, Anthony J. Filiano, Andrew E. Arrant, Erik D. Roberson, Timothy W. Kraft, - [R-Ras Contributes to LTP and Contextual Discrimination](https://virovek.com/2020/08/02/r-ras-contributes-to-ltp-and-contextual-discrimination/) - R-Ras Contributes to LTP and Contextual Discrimination Michael J. Darcy, Shan-Xue Jin, Larry A. Feig Neuroscience. Author manuscript; available in PMC 2015 Sep 26. Published in final edited form as: Neuroscience. 2014 Sep 26; 277: 334–342. Published online 2014 Jul 17. doi: 10.1016/j.neuroscience.2014.07.010 PMCID: PMC4164585 - [Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington’s disease](https://virovek.com/2020/08/02/impaired-trkb-receptor-signaling-underlies-corticostriatal-dysfunction-in-huntingtons-disease/) - Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington’s disease Joshua L. Plotkin, Michelle Day, Jayms D. Peterson, Zhong Xie, Geraldine J. Kress, Igor Rafalovich, Jyothisri Kondapalli, Tracy S. Gertler, Marc Flajolet, Paul Greengard, Mihaela Stavarache, Michael G. Kaplitt, Jim Rosinski, C. Savio Chan, D. James Surmeier Neuron. Author manuscript; available in PMC 2015 Jul - [ChR2 Mutants at L132 and T159 with Improved Operational Light Sensitivity for Vision Restoration](https://virovek.com/2020/08/02/chr2-mutants-at-l132-and-t159-with-improved-operational-light-sensitivity-for-vision-restoration/) - ChR2 Mutants at L132 and T159 with Improved Operational Light Sensitivity for Vision Restoration Zhuo-Hua Pan, Tushar H. Ganjawala, Qi Lu, Elena Ivanova, Zhifei Zhang PLoS One. 2014; 9(6): e98924. Published online 2014 Jun 5. doi: 10.1371/journal.pone.0098924 PMCID: PMC4047080 - [MRI-based detection of alkaline phosphatase gene reporter activity using a porphyrin solubility switch](https://virovek.com/2020/08/02/mri-based-detection-of-alkaline-phosphatase-gene-reporter-activity-using-a-porphyrin-solubility-switch/) - MRI-based detection of alkaline phosphatase gene reporter activity using a porphyrin solubility switch Gil G. Westmeyer, Elena G. Emer, Jutta Lintelmann, Alan Jasanoff Chem Biol. Author manuscript; available in PMC 2015 Mar 20. Published in final edited form as: Chem Biol. 2014 Mar 20; 21(3): 422–429. Published online 2014 Mar 6. doi: 10.1016/j.chembiol.2014.01.012 PMCID: PMC4073233 - [Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons](https://virovek.com/2020/08/02/regeneration-of-axons-in-injured-spinal-cord-by-activation-of-bone-morphogenetic-protein-smad1-signaling-pathway-in-adult-neurons-pranav-parikh-yuhan-hao-mohsen-hosseinkhani-shekhar-b-patil-georg/) - Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons Pranav Parikh, Yuhan Hao, Mohsen Hosseinkhani, Shekhar B. Patil, George W. Huntley, Marc Tessier-Lavigne, Hongyan Zou Proc Natl Acad Sci U S A. 2011 May 10; 108(19): E99–E107. Published online 2011 Apr 25. doi: 10.1073/pnas.11004261 - [Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways](https://virovek.com/2020/08/02/lkb1-regulates-organogenesis-and-early-oncogenesis-along-ampk-dependent-and-independent-pathways/) - Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways Bryan Lo, Geraldine Strasser, Meredith Sagolla, Cary D. Austin, Melissa Junttila, Ira Mellman J Cell Biol. 2012 Dec 24; 199(7): 1117–1130. doi: 10.1083/jcb.201208080 PMCID: PMC3529533 - [Safe, Long-term Hepatic Expression of Anti-HCV shRNA in a Nonhuman Primate Model](https://virovek.com/2020/08/02/safe-long-term-hepatic-expression-of-anti-hcv-shrna-in-a-nonhuman-primate-model/) ## Pages - [Home](https://virovek.com/) - Virovek’s patented BAC-to-AAV technology has the capability of generating up to 1E+17vg of adeno-associated virus in a single run. - [Technology Platforms](https://virovek.com/technology-platforms/) - Leaders in Viral Vector Manufacturing: AAV IN HEK293 CELLS, AAV IN SF9 CELLS, PACE, HIFI BACULOVIRUS, TOXIN DELIVERY BY AAV, LENTIVIRUS, ADONE ADENOVIRUS - [Company](https://virovek.com/company/) - A global leader in viral vector development, optimization, and manufacturing, empowering clients in their pursuit of transformative gene and cell therapies. - [404 - Page Not Found](https://virovek.com/404-page-not-found/) - 8300 Cypress Creek Parkway | Suite 100 | Houston, TX 77070 | P: 346.569.5012 | E: info@virovek.com - [Online Store](https://virovek.com/online-store/) - Virovek’s patented BAC-TO-AAV technology has the capability of generating up to 1E+17vg of adeno-associated virus in a single run. - [Contact Us](https://virovek.com/contact-us/) - 8300 Cypress Creek Parkway | Suite 100 | Houston, TX 77070 | P: 346.569.5012 | E: info@virovek.com - [Publications](https://virovek.com/publications/) - VIROVEK - Publications - [News](https://virovek.com/news/) - Follow our Newsroom for Virovek News, Press and Events - [Analytical Assays](https://virovek.com/analytical-assays/) - A comprehensive suite of cutting-edge analytical assays designed to support the development, characterization, and quality control of viral vectors and gene therapies - [Products & Services](https://virovek.com/products-services/) - High-quality viral vector manufacturing and purification services, including AAV, Lentivirus, Baculovirus, Adenovirus, Plasmids, Bacmids, Analytical Assays ## Portfolio - [Stockholm Fashion](https://virovek.com/portfolio_page/stockholm-fashion-destination/) - Lorem ipsum dolor sit amet, consectetuer adipiscing elit. 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