Publications
Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice
Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice Sam Hana, Michael Peterson, Helen McLaughlin, Eric Marshall, Attila J. Fabian, Olivia McKissick, Kathryn Koszka, Galina Marsh, Michael Craft,...
TPP Combined with DGUC as an Economic and Universal Process for Large-Scale Purification of AAV Vectors
TPP Combined with DGUC as an Economic and Universal Process for Large-Scale Purification of AAV Vectors Zhe Yu, Siyun Zhou, Ningguang Luo, Ching Yi Ho, Min Chen, Haifeng Chen Mol Ther Methods Clin Dev. 2020 Jun 12; 17:...
Exploiting the intron-splicing mechanism of insect cells to produce viral vectors harboring toxic genes for suicide gene therapy
Exploiting the intron-splicing mechanism of insect cells to produce viral vectors harboring toxic genes for suicide gene therapy Chen H. Mol Ther Nucleic Acids. 2012 Nov 27;1:e57.
Intron splicing-mediated expression of AAV Rep and Cap genes and production of AAV vectors in insect cells
Intron splicing-mediated expression of AAV Rep and Cap genes and production of AAV vectors in insect cells Chen H. Mol Ther. 2008 May;16(5):924-30. Epub 2008 Mar 18.
Selected Peer-Reviewed Articles using AAV Vectors Produced by VirovekKinetics and MR-Based Monitoring of AAV9 Vector Delivery into Cerebrospinal Fluid of Nonhuman PrimatesKousaku Ohno, Lluis Samaranch, Piotr Hadaczek, John R. Bringas, Philip C. Allen, Vivek Sudhakar,...
To transduce a zebra finch: interrogating behavioral mechanisms in a model system for speech
To transduce a zebra finch: interrogating behavioral mechanisms in a model system for speech Jonathan B. Heston, Stephanie A. White J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017; 203(9): 691–706. Published online 2017 Mar 7. doi:...
TRPC3 channels critically regulate hippocampal excitability and contextual fear memory
TRPC3 channels critically regulate hippocampal excitability and contextual fear memory Sarah M. Neuner, Lynda A. Wilmott, Kevin A. Hope, Brian Hoffmann, Jayhong A. Chong, Joel Abramowitz, Lutz Birnbaumer, Kristen O’Connell, Andrew K. Tryba, Andrew S. Greene, C. Savio...
Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons
Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons Luis Carrillo-Reid, Michelle Day, Zhong Xie, Alexandria E Melendez, Jyothisri Kondapalli, Joshua L Plotkin, David L Wokosin, Yu Chen, Geraldine J Kress, Michael...
Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships
Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships Peng Zhang, Hong Lu, Rui T. Peixoto, Mary K. Pines, Yuan Ge, Shinichiro Oku, Tabrez J. Siddiqui, Yicheng Xie, Wenlan Wu, Stephanie Archer-Hartmann, Keitaro Yoshida, Kenji F. Tanaka, A. Radu...
A role for cerebellum in the hereditary dystonia DYT1
A role for cerebellum in the hereditary dystonia DYT1 Rachel Fremont, Ambika Tewari, Chantal Angueyra, Kamran Khodakhah eLife. 2017; 6: e22775. Published online 2017 Feb 15. doi: 10.7554/eLife.22775 PMCID: PMC5340526
FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch
FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch Zachary Daniel Burkett, Nancy F Day, Todd Haswell Kimball, Caitlin M Aamodt, Jonathan B Heston, Austin T Hilliard, Xinshu Xiao, Stephanie A White eLife. 2018; 7:...
Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress
Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress Jaime N. Guzman, Ema Ilijic, Ben Yang, Javier Sanchez-Padilla, David Wokosin, Dan Galtieri, Jyothisri Kondapalli, Paul T. Schumacker, D. James Surmeier J Clin Invest. 2018 Jun 1;...
Behavior-Linked FoxP2 Regulation Enables Zebra Finch Vocal Learning
Behavior-Linked FoxP2 Regulation Enables Zebra Finch Vocal Learning Jonathan B. Heston, Stephanie A. White J Neurosci. 2015 Feb 18; 35(7): 2885–2894. doi: 10.1523/JNEUROSCI.3715-14.2015 PMCID: PMC4331621
Proteomics Analysis of Co-Purifying Cellular Proteins Associated with rAAV Vectors
Proteomics Analysis of Co-Purifying Cellular Proteins Associated with rAAV Vectors Biao Dong, Xunbao Duan, Hoi Yee Chow, Lingxia Chen, Hui Lu, Wenman Wu, Bernd Hauck, Fraser Wright, Philipp Kapranov, Weidong Xiao PLoS One. 2014; 9(2): e86453. Published online 2014 Feb...
Wilm’s tumor 1 promotes memory flexibility
Wilm’s tumor 1 promotes memory flexibility Chiara Mariottini, Leonardo Munari, Ellen Gunzel, Joseph M. Seco, Nikos Tzavaras, Jens Hansen, Sarah A. Stern, Virginia Gao, Hossein Aleyasin, Ali Sharma, Evren U. Azeloglu, Georgia E. Hodes, Scott J. Russo, Vicki Huff, Marc...
Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates
Viral-Mediated Optogenetic Stimulation of Peripheral Motor Nerves in Non-human Primates Jordan J. Williams, Alan M. Watson, Alberto L. Vazquez, Andrew B. Schwartz Front Neurosci. 2019; 13: 759. Published online 2019 Jul 31. doi: 10.3389/fnins.2019.00759 PMCID:...
Optogenetic Peripheral Nerve Immunogenicity
Optogenetic Peripheral Nerve Immunogenicity Benjamin E. Maimon, Maurizio Diaz, Emilie C. M. Revol, Alexis M. Schneider, Ben Leaker, Claudia E. Varela, Shriya Srinivasan, Matthew B. Weber, Hugh M. Herr Sci Rep. 2018; 8: 14076. Published online 2018 Sep 19. doi:...
Bidirectional scaling of vocal variability by an avian cortico‐basal ganglia circuit
Bidirectional scaling of vocal variability by an avian cortico‐basal ganglia circuit Jonathan B. Heston, Joseph Simon, IV, Nancy F. Day, Melissa J. Coleman, Stephanie A. White Physiol Rep. 2018 Apr; 6(8): e13638. Published online 2018 Apr 24. doi: 10.14814/phy2.13638...
A robust activity marking system for exploring active neuronal ensembles
A robust activity marking system for exploring active neuronal ensembles Milad Rezvani, Regina Español-Suñer, Yann Malato, Laure Dumont, Andrew A. Grimm, Eike Kienle, Julia G. Bindman, Ellen Wiedtke, Bernadette Y. Hsu, Syed J. Naqvi, Robert F. Schwabe, Carlos U....
In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis
In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis Milad Rezvani, Regina Español-Suñer, Yann Malato, Laure Dumont, Andrew A. Grimm, Eike Kienle, Julia G. Bindman, Ellen Wiedtke, Bernadette Y. Hsu, Syed J....